Hybrid multichannel printed circuit board microdrive

ABSTRACT

A miniature microdrive system may be affixed to the skull and used to advance recording electrode bundles or injection cannula through the brain of freely moving test subjects, e.g., rodents. The microdrive may be constructed using a hybrid fabrication technique utilizing a printed circuit board and a small number of mechanical parts. The printed circuit board provides the base for both the electrical components and the mechanical components. The movement of a screw advances a shuttle that in turn moves an electrode bundle through the brain. Independently moving screws advance independent electrode bundles. The electrode wires are connected through the printed circuit board to a connector on the back of the board. Stainless steel cannulae are soldered to a grounding trace on the printed circuit board to guide the electrode bundle and provide a ground connection. With this system, multiple brain structures may be targeted simultaneously. The microdrive system or device is simple to mass produce, making fabrication simple with parts that can be recycled or discarded as needed.

CROSS REFERENCE TO RELATED APPLICATION

The present application claims priority to U.S. Provisional Patent Application Ser. No. 60/981,579, filed Oct. 22, 2007, which is hereby incorporated by reference in its entirety.

FIELD OF THE INVENTION

The present invention relates generally to an integrated implanted cannula, microdrive, electrodes and electrode system, and more particularly, to a system which integrates a miniature microdrive and electrodes (or injection cannula) into a single package on a printed circuit board.

BACKGROUND OF THE INVENTION

The ability to probe multiple sites with the brain of a test subject, such as rodents or birds, simultaneously holds much potential in the biomedical field, especially for understanding the relationship between neuronal patterns and behavior.

The use of portable devices or systems which may be affixed to the test subject with microdrives for placement of the one or more electrodes has been known.

For example, two such systems are shown in:

1. Szabó, I, Czurkó, A, Csicsvari, J, Hirase, J, Leinekugal, X, Buszáki, G. The application of printed circuit board technology for fabrication of multi-channel micro-drives. Journal of Neuroscience Methods 105 (2001) 105-110.

2. Fee, M, Leonardo, A. Miniature motorized microdrive and commutator system for chronic recording in small animals. Journal of Neuroscience Methods 112 (2001) 83-94.

The Szabó reference discloses a micro-drive system. Not including the motors, these systems typically include three main components: (1) the microdrives, which typically include one or more micro-screws, (2) the electrodes, and (3) the electrical connectors for connecting the electrodes to off-system electronics for recording the signals from the electrodes.

As best can be seen in FIG. 5 of Szabó, the Szabó system includes 8 micro screws mounted between two parallel mounting boards. The micro screws drive individual electrodes which are fed through a separate member which is coupled to the mounting boards via a frame comprised of three framing members which are soldered to. The electrodes are electrically coupled to a connector which is mounted on a separate connector board. The connector board is affixed to the mounting boards via four additional framing members. As can be easily seen, the Szabó system is complex, made up a multitude of parts, which must be assembled in a complex, time consuming process. Furthermore, the three separate components are connected together via various framing members, which require frequent adjustment and repair.

As best can be seen in FIG. 3 of Fee, the Fee system also separates out the 3 main components of the system which each must be separately assembled and then assembled into a single unit, making the Fee system also difficult and time consuming to assembly and prone to breaking, requiring frequent repairs and adjustments.

The present invention is aimed at one or more of the following problems identified above.

SUMMARY OF THE INVENTION

In a first aspect of the present invention, an integrated microdrive and electrode system or device is provided. The microdrive includes one or more drive screws which may be adjusted manually or via a motor. The device may include a single or unitary base. The device positions and holds each screw in a position parallel to the board while allowing the screws to turn freely. The device includes a threaded shuttle which rides a respective screw. Movement of the shuttles advances/withdraws a respective electrode through a fixed cannulae, which is fixed to the board.

In a second aspect of the present invention, one or more of the components of the devices may be unitarily formed.

In a third aspect of the present invention, an apparatus having a base, a retaining bracket, a micro-screw, a cannula, a shuttle, and an electrode is provided. The base has a first surface and a second surface and a first end and a second end. The retaining bracket is mounted to the first surface of the base near the first end and has a bore parallel to a plane of the base. The micro-screw has a head and a shaft and is located within the bore. The head defines a shoulder which rests against one side of the retaining bracket. The shaft is threaded and extends through the bore towards the second end. The micro-screw is held along, and rotatable about, an axis parallel to the base, by the retaining bracket. The cannula has an internal bore and is mounted to the first surface. The shuttle has a bore with internal threads which are in a coupling relationship with the threads of the micro-screw. The micro-screw is rotatable in a first rotary direction causing the shuttle to be advanced along the micro-screw in a first direction and in a second rotary direction causing the shuttle to be advanced along the micro-screw in a second direction. The electrode has a first end and a second end and is coupled to the shuttle. The second end of the electrode is threaded through the cannula such that motion of the shuttle along the micro-screw moves the electrode through the cannula.

In a fourth aspect of the present invention, an apparatus having a base, a retaining bracket, first and second micro-screws, a first cannula, a second cannula, first and second shuttles, and first and second electrodes is provided. The base has a first surface and a second surface and a first end and a second end. The retaining bracket is mounted to the first surface of the base near the first end and has a bore parallel to a plane of the base. The first micro-screw has a head and a shaft and is located within the bore. The head defines a shoulder which rests against one side of the retaining bracket. The shaft is threaded and extends through the bore towards the second end. The first micro-screw is held along, and rotatable about, an axis parallel to the base, by the retaining bracket. The first cannula has an internal bore and is mounted to the first surface. The first shuttle has a bore with internal threads which are in a coupling relationship with the threads of the first micro-screw. The first micro-screw is rotatable in a first rotary direction causing the shuttle to be advanced along the first micro-screw in a first direction and in a second rotary direction causing the shuttle to be advanced along the first micro-screw in a second direction. The first electrode has a first end and a second end and is coupled to the first shuttle. The second end of the first electrode is threaded through the first cannula such that motion of the first shuttle along the first micro-screw moves the electrode through the first cannula. The second micro-screw has a head and a shaft and is located within a second bore of the retaining bracket. The head of the second micro-screw defines a shoulder which rests against the one side of the retaining bracket. The shaft of the second micro-screw is threaded and extends through the second bore towards the second end. The second micro-screw is held along, and rotatable about, the axis parallel to the base, by the retaining bracket. The second cannula has an internal bore and is mounted to the first surface. The second shuttle has a bore with internal threads which are in a coupling relationship with the threads of the second micro-screw. The second micro-screw is rotatable in the first rotary direction causing the second shuttle to be advanced along the second micro-screw in the first direction and in the second rotary direction causing the second shuttle to be advanced along the second micro-screw in the second direction. The second electrode has a first end and a second end and is coupled to the second shuttle. The second end of the second electrode is threaded through the second cannula such that motion of the second shuttle along the second micro-screw moves the second electrode through the second cannula.

BRIEF DESCRIPTION OF THE DRAWINGS

Other advantages of the present invention will be readily appreciated as the same becomes better understood by reference to the following detailed description when considered in connection with the accompanying drawings wherein:

FIGS. 1A is a top view of an integrated micro drive and electrode system, according to an embodiment of the present invention;

FIG. 1B is a side view of the system of FIG. 1A;

FIG. 1C is a cut away of the system of FIG. 1A;

FIG. 1D is an end view of the system of FIG. 1A;

FIG. 1E is a top view of a cover of the system of FIG. 1A;

FIG. 1F is an end view of the cover of FIG. 1E;

FIG. 1G is a component view of several components of the system of FIG. 1A;

FIG. 1H is a first view of a screw retainer;

FIG. 1I is a second view of the screw retainer;

FIG. 1J is a view of a securing hook, a shuttle, and a micro-screw of the system of FIG. 1A;

FIGS. 2A is a top view of an integrated micro drive and electrode system, according to another embodiment of the present invention;

FIG. 2B is a side view of the system of FIG. 2A;

FIG. 2C is a cut away of the system of FIG. 2A;

FIG. 2D is a first front view of the system of FIG. 2A;

FIG. 2E is a second end view of a retaining bracket of the system of FIG. 2A;

FIG. 2F is a first end view of the retaining bracket of the system of FIG. 2A;

FIG. 2G is a component view of several components of the system of FIG. 2A;

FIG. 3A is a top view of an integrated micro drive and electrode system, according to a third embodiment of the present invention;

FIG. 3B is a second top view of the system of FIG. 3A;

FIG. 3C is a second end view of the system of FIG. 3A;

FIG. 3D is a first end view of the system of FIG. 3A;

FIG. 3E is a side view of the system of FIG. 3A;

FIG. 3F is a bottom view of the system of FIG. 3A;

FIG. 3G is a cut-away view of the system of FIG. 3A;

FIG. 3H is a component view of the system of FIG. 3A;

FIG. 3I is a first end view of an integrated cover and bracket of the system of FIG. 3A;

FIG. 3J is a top view of the integrated cover and bracket of FIG. 3I; and

FIG. 3K is a second end view of the integrated cover and bracket of FIG. 3J.

DETAILED DESCRIPTION OF INVENTION

Referring to the Figures, wherein like numerals indicate like or corresponding parts throughout the several views, the present invention provides an integrated microdrive and electrode system or device 100, 200, 300 which is capable of advancing independent electrodes for the independent recording at multiple sites within the brain of test subjects, e.g., rodents, birds, etc.

The integrated device 100, 200, 300 may be affixed outside the skull of the subject with the electrodes inserted or implanted through the skull and into the brain of the subject. As discussed below, the micro-drive may include one or more micro-screws 102, 202, 302, which may be adjusted either manually or via a motor (not shown) for adjusting, i.e., advancing or withdrawing, an electrode. It should be noted that the present invention is described and shown with four micro-screws for individually adjusting four electrodes, although any number may be provided.

With particular reference to FIGS. 1A-1J, in one aspect of the present invention, an example of which is shown in, the device 100 is integrated onto a single or unitary base 104, such as a printed circuit (PC) board. In the illustrated embodiment, the base 104 is a double sided printed circuit board. The design of the printed circuit board 104 is such that it provides a base for all the components (see below).

In the illustrated embodiment, four drive screws 102A, 102B, 102C, 102D, which are typically 0-80 size or metric screws of a comparable size, are positioned parallel to one face (or surface) 104A of the printed circuit board 104. The head 108A, 108B, 108C, 108D of each screw 102A, 102B, 102C, 102D rests in a respective hole or aperture 106C, 106D of the circuit board 104. The holes 106A, 106B, 106C, 106D provide a shoulder to accurately locate the position of the respective screw 102A, 102B, 102C, 102D with the shaft 110A, 110B, 110C, 110D of each screw 102A, 102B, 102C, 102D flat against and guided by the circuit board 104. The screws 102A, 102B, 102C, 102D are held in place by a retaining bracket 112 just below the head 108, 108, 108, 108 of each screw 102A, 102B, 102C, 102D and respective stabilizing hooks 112A, 112B, 112C, 112D located in the shaft end of each screw 102A, 102B, 102C, 102D.

In the illustrated embodiment, the retaining bracket 113 is integral and mounted to the PC board 104 by one or more fasteners (not shown) inserted through bores 114. The stabilizing hooks 112A, 112B, 112C, 112D are affixed in respective holes or apertures 116A, 116B, 116C, 116D in the PC board 104. The retaining bracket 113, stabilizing hooks 112A, 112B, 112C, 112D and the hole-in-the-board are configured to hold the screws 102A, 102B, 102C, 102D securely in position, yet allow the screws 102A, 102B, 102C, 102D to turn freely.

A respective threaded shuttle 118A, 118B, 118C, 118D rides on each screw 102A, 102B, 102C, 102D. Like the screws 102A, 102B, 102C, 102D, the printed circuit board 104 provides guidance and a stable sliding surface for the shuttles 118A, 118B, 118C, 118D. The internal threads of the shuttles 118A, 118B, 118C, 118D couple with the threads of the screws 102A, 102B, 102C, 102D so as to move the shuttles 118A, 118B, 118C, 118D across the board 104 as the respective screw 102A, 102B, 102C, 102D is turned.

A flexible fused silica cannula 120A, 120B, 120C, 120D is secured in a groove 122 on a respective shuttle 118A, 118B, 118C, 118D with epoxy. The fused silica cannula 120A, 120B, 120C, 120D is guided by a hollow stationary stainless steel cannula 124 soldered on the printed circuit board 104. In the illustrated embodiment, only one stationary cannula 124 is shown, but it should be noted that any desired combination and position (one to four cannulae) and positioned along the printed circuit board 104 may be utilized.

In operation as a drive or micro-screw 102A, 102B, 102C, 102D is turned, the respective shuttle 118A, 118B, 118C, 118D moves up or down the shaft 110A, 110B, 110C, 110D of the screw 102A, 102B, 102C, 102D, which in turn pushes or pulls the flexible cannula 120A, 120B, 120C, 120D through the stationary cannula 124. The flexible cannula 120A, 120B, 120C, 120D carries an electrode bundle 126 which includes a plurality of wires 128, e.g., four wires. The electrode bundle 126 includes a first end 126A and a second end 126B. An electrode (not shown) is coupled to the second end 126B of the electrode bundle 126. The flexible cannulas 120A, 120B, 120C, 120D carry the electrode wires 128 with it allowing the electrode wires 128 to be moved precisely through the brain tissue.

The electrode wires 128 that feed into the flexible cannula 120A, 120B, 120C, 120D pass through the printed circuit board 104 and attach to a surface mount connector 130 on the reverse side 104B of the board 104 through connection holes 136.

A cover 132 may be attached to the top of the retainer bracket 113, protecting the exposed wires and moving parts. The cover 132 may be made of clear plastic or may have a number of viewing ports (as shown in FIG. 2B) and may be coupled to the board 104 using the fasteners 115 through bores 132A.

With particular reference to FIGS. 2A-2G, in an alternate embodiment in which like parts or numbered in a similar manner, one or more of the components of an integrated microdrive and electrode system or device, may be unitarily formed, e.g., out of plastic using an injection molding process. For example, in the illustrated embodiment, the board 204, a screw retainer 213 may be unitarily formed. An electrical connector 230 (or provisions for the mounting thereof), may also be included in the unitarily formed piece.

The screw retainer 213 replaces the retaining bracket 113 and the separate stabilizing hooks 112A, 112B, 112C, 112D of the first embodiment. The screw retainer 213 includes a first side 213A with a plurality of U-shaped apertures 214 through which the shafts 210 of the micro-screws 102 are inserted and which may form, along with the base 204, a shoulder for the heads 108A, 108B, 108C, 108D of the micro-screws 102. The opposite side of the screw retainer 213 (see FIG. 2E) retains the end of the micro-screw 102 opposite the head 108 in position.

A cover 232, which may also be injection molded, may also be provided. In one embodiment, the cover snaps onto the device or may be connected to the board 204, or the screw retainer 213 by a living hinge. The cover 232 may includes a plurality of viewing windows 232A (see FIG. 2A).

Additionally, in the alternative embodiment two stationery cannulae 224A, 224B are used. Each stationery cannula 224A, 224B is used to guide two sets of electrode bundles 226A & 226B, 226C & 226D.

With particular reference to FIGS. 3A-3K, in an alternate embodiment in which like parts or numbered in a similar manner, one or more of the components of an integrated micro drive and electrode system or device, may be unitarily formed, e.g., out of plastic using an injection molding process. For example, in the illustrated embodiment, the board 304 and a screw retainer may be unitarily formed. An electrical connector (or provisions for the mounting thereof), may also be included in the unitarily formed piece.

In the illustrated embodiment, the cover 232 of the embodiment in FIGS. 2A-2G is replaced by an integrated cover/retainer 332 (see FIGS. 3I, 3J, 3K). The integrated cover/retainer 332 has a first end 332A which includes apertures 332C for positioning the heads 308A, 308B, 308C, 308D of the micro-screws 302 and a second end 332B which is used to maintain the position of the opposite end of the micro-screws 302. The integrated cover/retainer 332 may be made of clear plastic.

In operation, the device 100, 200, 300, allows a plurality of electrode bundles 126, 226, 336, e.g., but not limited to, 4, to be independently advanced or withdrawn in (brain tissue). The device 100, 200, 300, as described herein, utilizes simple mechanical parts mounted to a common board, such as a PC board, combining the mechanical and electrical micro-drive components into a single package. This provides a device 100, 200, 300 that is robust, easy to manufacture and to assemble, durable, and reusable. In addition, the device is inexpensive to manufacture and may be disposable.

Obviously, many modifications and variations of the present invention are possible in light of the above teachings. 

1. An apparatus, comprising: a base having a first surface and a second surface and a first end and a second end; a retaining bracket mounted to the first surface of the base near the first end, the bracket having a bore parallel to a plane of the base; a micro-screw having a head and a shaft and being located within the bore, the head defining a shoulder which rests against one side of the retaining bracket, the shaft being threaded and extending through the bore towards the second end, the micro-screw being held along, and rotatable about, an axis parallel to the base, by the retaining bracket; a cannula having an internal bore and being mounted to the first surface; a shuttle having a bore with internal threads, the internal threads of the bore of the shuttle being in a coupling relationship with the threads of the micro-screw, the micro-screw being rotatable in a first rotary direction causing the shuttle to be advanced along the micro-screw in a first direction, the micro-screw being rotatable in a second rotary direction causing the shuttle to be advanced along the micro-screw in a second direction; and, an electrode having a first end and a second end and being coupled to the shuttle, the second end of the electrode being threaded through the cannula such that motion of the shuttle along the micro-screw moves the electrode through the cannula.
 2. An apparatus, as set forth in claim 1, including: a second micro-screw having a head and a shaft and being located within a second bore of the retaining bracket, the head of the second micro-screw defining a shoulder which rests against the one side of the retaining bracket, the shaft of the second micro-screw being threaded and extending through the second bore towards the second end, the second micro-screw being held along, and rotatable about, the axis parallel to the base, by the retaining bracket; a second shuttle having a bore with internal threads, the internal threads of the bore of the second shuttle being in a coupling relationship with the threads of the second micro-screw, the second micro-screw being rotatable in the first rotary direction causing the second shuttle to be advanced along the second micro-screw in the first direction, the second micro-screw being rotatable in a second rotary direction causing the second shuttle to be advanced along the second micro-screw in the second direction; and, a second electrode having a first end and a second end and being coupled to the second shuttle, the second end of the second electrode being threaded through the cannula such that motion of the second shuttle along the second micro-screw moves the second electrode through the cannula.
 3. An apparatus, as set forth in claim 1, further comprising a flexible cannula secured within a groove of the shuttle, the electrode being secured within the flexible cannula.
 4. An apparatus, as set forth in claim 1, the base having an aperture, the head of the micro-screw being partially located within the aperture.
 5. An apparatus, as set forth in claim 1, wherein the retaining bracket is secured to the base by one or more fasteners.
 6. An apparatus, as set forth in claim 1, wherein the retaining bracket is integral with the base.
 7. An apparatus, as set forth in claim 1, wherein the first surface of the base provides a guides and a stable sliding surface for the shuttle.
 8. An apparatus, as set forth in claim 1, further comprising a surface mount connector mount on the second surface of the base, the electrode being electrically coupled to the surface mount connector.
 9. An apparatus, as set forth in claim 8, the surface mount connecter having at least one pin, the first end of the electrode being electrically connected to the pin.
 10. An apparatus, as set forth in claim 8, wherein the electrode includes a plurality of electrode wires, each wire having a first end which is electrically connected to a separate pin of the surface mount connecter.
 11. An apparatus, as set forth in claim 1, further comprising a cover attached to a top of the retainer bracket.
 12. An apparatus, as set forth in 11, wherein the base, retaining bracket and cover are unitarily formed and further comprising a living hinge coupling the base and the cover.
 13. An apparatus, as set forth in claim 1, the shaft having an end opposite the head, the end having an internal bore, further including a stabilizing hook fixed to the base and having a hook end extending into the internal bore of the end of the micro-screw.
 14. An apparatus, comprising: a base having a first surface and a second surface and a first end and a second end; a retaining bracket mounted to the first surface of the base near the first end, the bracket having a bore parallel to a plane of the base; a first micro-screw having a head and a shaft and being located within the bore, the head defining a shoulder which rests against one side of the retaining bracket, the shaft being threaded and extending through the bore towards the second end, the first micro-screw being held along, and rotatable about, an axis parallel to the base, by the retaining bracket; a first cannula having an internal bore and being mounted to the first surface; a first shuttle having a bore with internal threads, the internal threads of the bore of the shuttle being in a coupling relationship with the threads of the micro-screw, the micro-screw being rotatable in a first rotary direction causing the shuttle to be advanced along the micro-screw in a first direction, the micro-screw being rotatable in a second rotary direction causing the shuttle to be advanced along the micro-screw in a second direction; a first electrode having a first end and a second end and being coupled to the shuttle, the second end of the first electrode being threaded through the first cannula such that motion of the first shuttle along the first micro-screw moves the electrode through the cannula; a second micro-screw having a head and a shaft and being located within a second bore of the retaining bracket, the head of the second micro-screw defining a shoulder which rests against the one side of the retaining bracket, the shaft of the second micro-screw being threaded and extending through the second bore towards the second end, the second micro-screw being held along, and rotatable about, the axis parallel to the base, by the retaining bracket; a second cannula having an internal bore and being mounted to the first surface; a second shuttle having a bore with internal threads, the internal threads of the bore of the second shuttle being in a coupling relationship with the threads of the second micro-screw, the second micro-screw being rotatable in the first rotary direction causing the second shuttle to be advanced along the second micro-screw in the first direction, the second micro-screw being rotatable in a second rotary direction causing the second shuttle to be advanced along the second micro-screw in the second direction; and, a second electrode having a first end and a second end and being coupled to the second shuttle, the second end of the second electrode being threaded through the second cannula such that motion of the second shuttle along the second micro-screw moves the second electrode through the second cannula.
 15. An apparatus, as set forth in claim 14, further comprising: a first flexible cannula secured within a groove of the first shuttle, the first electrode being secured within the flexible cannula; and a second flexible cannula secured within a groove of the second shuttle, the second electrode being secured within the flexible cannula; and
 16. An apparatus, as set forth in claim 14, the base having first and second apertures, the head of the first and second micro-screws being partially located within the first and second apertures, respectively.
 17. An apparatus, as set forth in claim 14, wherein the retaining bracket is secured to the base by one or more fasteners.
 18. An apparatus, as set forth in claim 14, wherein the retaining bracket is integral with the base.
 19. An apparatus, as set forth in claim 14, wherein the first surface of the base provides a guides and a stable sliding surface for the first and second shuttles.
 20. An apparatus, as set forth in claim 14, further comprising a surface mount connector mount on the second surface of the base, the first and second electrodes being electrically coupled to the surface mount connector.
 21. An apparatus, as set forth in claim 20, the surface mount connecter having at least one pin, the first end of the electrode being electrically connected to the pin.
 22. An apparatus, as set forth in claim 20, wherein each electrode includes a plurality of electrode wires, each wire having a first end which is electrically connected to a separate pin of the surface mount connecter.
 23. An apparatus, as set forth in claim 14, further comprising a cover attached to a top of the retainer bracket.
 24. An apparatus, as set forth in 23, wherein the retaining bracket and cover are unitarily formed. 